Level 4 Laser Therapy

• Burn Wound Healing
• Acute orthopedic conditions such as sprains, strains, post-surgical pain, a whiplash injury , muscular back pain, cervical or lumbar radiculopathy
• Tendinitis and chronic conditions such as osteoarthritis , rheumatoid arthritis, frozen shoulder , neck and Back pain ,epicondylitis, carpal tunnel syndrome, tendinopathy , fibromyalgia ,plantar fasciitis
• Post tibial fracture surgery and chronic regional pain syndrome

1. High Power: This feature allows for a reduction in treatment time.

2. Adjustable Treatment: Both treatment duration and power intensity can be modified at any moment.

3. User-Friendly Settings: Each adjustment results in a 3-second output from the device.

4. Custom Options: For 904nm/830nm/450nm wavelengths or 5W/10W/35W/75W power settings, as well as rental models, please contact us directly.

5. Portability: Easy to carry and elegant in design, we also offer free treatment protocols.

6. Package Includes: 1x Pain relief low-level cold laser device, 1x Power adapter, 1x Suitcase, 1x Manual, 1x Warranty card, 2x Safety glasses with case, 1x Stand

Level 4 laser therapy photons are absorbed in the cells through the mitochondria organelle. Mitochondria cytochromes use these photons in order to synthesize ATP. ATP production as the main source of cell energy induces cellular events such as DNA synthesis and replication, cell proliferation, cell differentiation, and protein synthesis.Moreover, Level 4 laser therapy regulates cell metabolism through the induction of two key players of the respiratory chain, NADH-dehydrogenase and cytochrome c oxidase. As a result, cell growth is stimulated.

Studies indicated that Level 4 laser therapy induced tissue remodeling and regeneration. It could increase fibroblast, endothelial and keratinocytes growth, and it enhanced collagen release which is important for the wound healing process. Level 4 laser therapy could also stimulate angiogenesis, and it improved blood flow in the tissue. In this manner, Level 4 laser therapy decreased acidosis and caused pain relief.

Burn Wound Healing Mechanisms

Burn wounds face challenges in healing due to disrupted epidermal barriers, impaired blood flow, weakened defense mechanisms, pathological inflammation, and potential septicemia. Previous findings indicated that superpulsed 904nm Low-Level Laser Therapy (LLLT) improved healing and reduced inflammation in burn wounds.



This study explored the effects of superpulsed 904nm LLLT (200ns pulse width; 100Hz; 0.7mW mean output power; 0.4mW/cm² average irradiance) on bioenergetics and redox homeostasis markers in full-thickness burn wounds in experimental rats. The results showed that seven days of laser treatment post-injury promoted a shift towards aerobic metabolism, evidenced by significantly increased activities of key energy-regulating enzymes such as hexokinase (HK), phosphofructokinase (PFK), citrate synthase (CS), and glucose-6-phosphate dehydrogenase (G6PD), with a corresponding decrease in lactate dehydrogenase (LDH) activity compared to non-irradiated controls.



LLLT also significantly increased cytochrome c oxidase (CCO) activity and ATP levels. Additionally, LLLT regulated redox balance, shown by increased NADPH levels and a reduced NADP/NADPH ratio. Western blot analysis revealed that LLLT upregulated glucose transporter 1 (GLUT1) and phosphorylated AMP-activated protein kinase alpha (pAMPKα), while downregulating glycogen synthase 1 (GS1).



These findings suggest that superpulsed 904nm LLLT enhances burn wound healing by boosting intracellular energy through the modulation of aerobic metabolism for optimal energy production. The activation of bioenergetics and maintenance of redox balance are likely key mechanisms behind the beneficial effects of near-infrared photobiomodulation in burn wound healing.