What are the indications of COZING-C320 brain photobiomodulation devices?
Dementia
Alzheimer's
Traumatic Brain Injury
Parkinson's
Post Traumatic Stress Disorder (PTSD)
Autism Spectrum Disorder
What is Brain Photobiomodulation?
Brain photobiomodulation refers to the use of LED or laser light directed at the skull. This low-power light penetrates brain tissue, stimulating the mitochondria in nerve cells to increase ATP production, thereby promoting cellular regeneration and repair. This process enhances neuronal connections, brain plasticity, and ultimately improves cognitive function.
What the advantages of C320 brain photobiomodulation devices?
Brain light+intransal laser therpay, The neuro-vagal system forms a powerful photobiomodulatory system.
12 treatment zones,we can increase the abnormal part dosage,time and freuqncy, thus to Improves cognition, cerebral blood flow and brain health.
It is comine the ear laser, nose laser and brain therapy into one device.
What's the technical parameter of the COZING-C320 brain photobiomodulation devices?
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Number of diodes: |
320 LEDs |
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Wavelength: |
1070nm±20nm |
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Frequency: |
1-20,000 Hz can be adjusted |
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The default frequency setting: |
Pulse setting:10Hz CW setting:40Hz While the frequency is 1-20000Hz as adjusted |
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Duration: |
0-30 minutes adjustable |
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The intensity of the LED: |
10 levels as the options |
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Remote controller: |
wireless remote controller |
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Total Max. output power : |
16W |
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Single LED max. output power: |
50mW |
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Operation: |
It can be controlled manually or by remote controller |
COZING-C320 brain photobiomodulation devices Clinical study:
1.Background
Parkinson's disease (PD) is a progressive neurodegenerative disorder with no known cure and limited treatment options. Its prevalence is increasing due to aging populations, longer disease durations, and potentially as a sequela of COVID-19. Photobiomodulation (PBM) has shown promise in animal models, reducing PD symptoms and protecting dopaminergic neurons.
2.Objective
This proof-of-concept study aimed to evaluate the effectiveness of PBM in alleviating clinical symptoms of PD using a combination of transcranial and remote treatments. The findings will inform the design of a larger randomized placebo-controlled trial (RCT).
3.Methods
Twelve participants with idiopathic PD were recruited. Six began a 12-week PBM treatment regimen involving transcranial, intranasal, neck, and abdominal applications, while the other six were waitlisted for 14 weeks before starting the same treatment. After the 12-week treatment, all participants received PBM devices for continued home use. Assessments of mobility, fine motor skills, balance, and cognition were conducted at baseline, after 4 weeks, after 12 weeks, and at the end of the home treatment period. A Wilcoxon Signed Ranks test evaluated treatment effectiveness with a significance level of 5%.
4.Results
PBM treatment significantly improved mobility, cognition, dynamic balance, and fine motor skills (p < 0.05) after 12 weeks and sustained improvements were observed for up to one year with home treatment. Many individual improvements exceeded the minimal clinically important difference, indicating meaningful benefits for participants. Variations in individual outcomes were noted, but continued treatment maintained improvements. A minor Hawthorne Effect was observed but was overshadowed by the treatment effect. No side effects were reported.
5.Conclusions
PBM appears to be a safe and potentially effective therapy for various PD symptoms. Improvements persisted for as long as treatment continued, even up to one year, in a condition where progressive decline is expected. Home-based PBM treatment, either self-administered or assisted by a caregiver, could be a viable therapeutic option. These findings support the need for a larger RCT to further evaluate PBM's efficacy in PD management.
1.Transcranial Functional Neuromodulation Stimulation (t-FNS) is a therapeutic approach that leverages phototherapy to enhance brain function and address various neurological disorders. The method involves directing low-intensity light waves, emitted by lasers or LED sources, to specific regions of the brain. This light energy is absorbed by mitochondria within cells, triggering biochemical reactions that improve cellular metabolism.
As a next-generation brain stimulation device, t-FNS is safe, effective, and user-friendly. It utilizes patented transcranial-transnasal technology, offering significant advantages in comprehensively stimulating the brain's default mode network.
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