Photobiomodulation ForAlzheimer

Alzheimer's disease is a devastating neurodegenerative disorder characterized by progressive cognitive impairment, memory loss, and behavioral changes.

While there is no known cure for Alzheimer's disease, recent research suggests that photobiomodulation (PBM), also known as low-intensity light therapy or light therapy, may have the potential to slow or even reverse the progression of Alzheimer's disease.

What's the principle of the COZING-C320 Photobiomodulation for Alzheimer's?

Photobiomodulation involves utilizing low levels of light energy to stimulate cellular function and promote healing. The brain is particularly sensitive to light, and studies have shown that photobiomodulation can improve brain function by increasing blood flow, reducing inflammation, and promoting the growth of new neurons and blood vessels.

Benefits of PBM in the Pathophysiology of Alzheimer's Disease

Lowering Amyloid Beta Protein Levels

PBM reduces amyloid beta protein levels in the brain.

Stimulates autophagy

PBM has been shown to stimulate autophagy in brain cells, which helps remove amyloid beta protein.

Neuroprotection

Photobiomodulation is neuroprotective, protecting neurons from damage.

Anti-inflammatory effects

Photobiomodulation has anti-inflammatory effects that reduce inflammation in the brain.

Increase BDNF production

Photobiomodulation increases the production of BDNF, thereby improving neuronal function.

1 . Animal models

One compelling study was conducted in an AβPP transgenic mouse with AD. Starting at 3 months of age, tPBM (1050 nm laser) was injected at different doses 3 times a week for 6 months. The number of Aβ plaques in the brain was significantly reduced with dose-dependent tPBM administration. tPBM attenuated the behavioral effects seen with advanced amyloid deposition and reduced the expression of inflammatory markers in the transgenic mice. In addition, TLT showed increased ATP levels, mitochondrial function, and c-fos expression, suggesting an overall improvement in neurologic function.

2. Humans

One group of researchers used helmets equipped with 1050 nm LEDs to treat AD, but surprisingly, there are no peer-reviewed publications describing this approach. However, a small pilot study (19 patients) in the form of a randomized placebo-controlled trial investigated the effects of the COIZNG Neuro System (a combination of tPBM and intranasal PBM) in patients with dementia and mild cognitive impairment . This was a controlled, single-blind pilot study in humans to investigate the effects of PBM on memory and cognition.19 Participants with memory/cognitive impairment were randomized to an active treatment group and a sham treatment group over a 12-week period , followed by a 4-week non-treatment follow-up period. They were assessed with the MMSE and ADAS-cog scales. The program involved the use of a combined intracranial-intranasal PBM device in the clinic; and a transnasal-only PBM device at home, with participants/caregivers recording daily experiences in a diary. Active participants with moderate to severe impairments (MMSE scores 5-24) showed significant improvement (5-point MMSE scores) after 12 weeks.ADAS-cog scores also improved significantly. They also reported better sleep, fewer anger outbursts, and reduced anxiety and wandering. Decreases were noted during the 4-week treatment-free follow-up. Participants in both the active and sham surgery subgroups with mild to normal impairment (MMSE scores of 25 to 30) demonstrated improvement. No associated adverse events were reported.

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